Specifically, NOG mutations are described to cause proximal symphalangism (SYM1; OMIM #185800), multiple synostosis syndrome (SYNS, OMIM: #186500), tarsal-carpal coalition syndrome (TCC; OMIM #186570), stapes ankylosis with broad thumbs and toes (OMIM #184460), and brachydactyly type B2 (BDB2; OMIM #611377) as recently reviewed by Potti et al. [10]. The gene discussed is NOG; the disease is tarsal-carpal coalition syndrome.