PTX3 and asthma: In light of prior evidence and present data, it is tempting to speculate that PTX3-mediated CCL11/eotaxin-1 release may down-regulate exaggerated neutrophilic inflammation by suppressing CXC chemokine release during acute inflammation, hence creating a negative feedback to establish tissue homeostasis especially in severe asthma that is characterized by more neutrophilic infiltrates [55].