However, it is worth mentioning that CCL11/eotaxin-1, besides its role in attracting eosinophils, can exert a specific regulatory function of neutrophil recruitment in vivo as has been shown in a mouse model of endotoxemia [53] via probable down-regulation of CXC chemokine CXCL8/IL-8 [54]. This evidence concerns the gene CXCL8 and serum lipopolysaccharide activity.