ALDH18A1 and parasitic infectious disease: We found that mice immunized following the prime-boost immunization scheme had very low levels of the parasite load in the liver, with an 86% percent reduction when the dose of PPV-PYCS was 50 μg and 81% reduction in parasitemia with a dose of 10 μg (Figure 3; p<0.001 by one-way ANOVA).