EGFR and urinary bladder cancer: Using the bladder cancer cell line 5637 and the cervical cancer cell line HeLa, which is an established in vitro model for studying both HER1 and CXCR4 signaling [4], [27], we found that CXCL12 elicits a calmodulin/calcineurin pathway, thereby delaying the autophosphorylation peak of HER1.