Furthermore, in studying the CXCL12-induced phosphoproteome adjustments in Hodgkin's lymphoma-derived L540 cells, which do not express HER1 but other HER receptors, we found that HER2 phosphorylation is strongly downregulated 20 minutes after stimulation with CXCL12. The gene discussed is CXCL12; the disease is Hodgkins lymphoma.