Interestingly, the frequency of the reported risk allele is higher in Europe than in Antioquia at five of the six markers showing nominal significant association (Figure 1), the largest difference (∼20%) being observed for rs7903146 in TCF7L2, which is the most robustly replicated T2D susceptibility locus and the one associated with the highest OR (∼1.3) [19]. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.