A second polymorphism in TLR1, N248S (A743G), is in strong linkage disequilibrium with the TLR1 602I allele which may explain the finding, observed in a Bangladesh cohort of leprosy patients, that M. leprae  infection associates with the TLR1 248S/S genotype (OR = 1.34, P = 0.02) [37, 39, 42]. Here, TLR1 is linked to leprosy.