SOD3 and arthritic joint disease: Similarly to the wild-type mice, Ade-SOD3 treatment in Ncf1∗/∗ paws induced significantly smaller difference between the virus-treated and PBS-injected paws than Ade-LacZ virus injection (significant d24 and d25 after immunization), again confirming the arthritis limiting effect of SOD3 (Figure 3(b)).