TLX1 (HOX11) is expressed at high level in more than 30 % of adult T-ALL as consequence of t(10;14)(q24;q11) and t(7;10)(q34;q24), while TLX3 (HOX11L2) is involved in t(5;14)(q35;q32) with the fusion partner BCL11B in about 20 % of children and 4 % of adults [64]. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.