TAL1 (1p32) is ectopically expressed in T-ALL as consequence of t(1;14)(p32;q11) [59] (3 % in childhood T-ALL) and more frequently as a consequence of the intrachromosomal deletion resulting in SIL-TAL1 fusion gene, while LYL1 (19p13), TAL2 (9q32), and BHLH1 (21q22) are up-regulated in the rare translocations t(7;19)(q34;p13), t(7;9)(q34;q32), and t(14;21)(q11;q22), respectively. The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.