Mice in both the AD + DW and AD + OPP groups showed significant changes in terms of serum clinical biochemistry, including albumin (↓), globulin (↑), ratio of albumin to globulin (↓), total cholesterol (↑), LDL (↑) and HDL (↑) levels (Online Resource 3 in Supplementary Material 1), when compared to those in the ND + DW group. This evidence concerns the gene ALB and Alzheimer disease.