GPX1 and Alzheimer disease: In the hearts of mice belonging to the AD + OPP group, genes up-regulated when compared to those of mice belonging to the AD + DW group include antioxidant genes, such as Mgst1 (microsomal glutathione S-transferase 1) (FC 1.71) and Gpx1 (glutathione peroxidase 1) (FC 1.24).