CD5 and B-cell chronic lymphocytic leukemia: On the other hand, a normal B cell that acquires autoreactivity during a somatic hypermutation process successfully undergoes receptor revision, anergy, CD5 expression and possible germinal center exclusion, leading to mutated CLL cells without autoreactivity or anergy, and only with self-renewing, low/absent BCR signaling and good prognosis (Fig. 2).