IDUA and Scheie syndrome: Mucopolysaccharidosis type I (MPS I; OMIM #252800) is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in the alpha-L-iduronidase (IDUA) enzyme, which is involved in the breakdown of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate [1].