In contrast to anti-proliferative findings of COG 112 and COG 133 peptides in lymphocyte cultures after myelin oligodendrocyte glycoprotein (MOG) exposure in a murine model of multiple sclerosis [11], our in vitro data in crypt IEC-6 cells in addition to the observation of improved crypt histology in treated mice suggest a beneficial role of the peptide in improving cell viability and crypt cell renewal following 5-FU challenge. This evidence concerns the gene MOG and multiple sclerosis.