The fact that the ALDH2 transgene reconciled STZ-induced intracellular Ca2+ mishandling favors a possible role of intracellular Ca2+ homeostasis in diabetes-induced myocardial dysfunction and ALDH2-offered protection, somewhat reminiscent of the beneficial role of mitochondrial protection against diabetes or obesity-induced myocardial dysfunction [31,32]. The gene discussed is ALDH2; the disease is obesity due to melanocortin 4 receptor deficiency.