In this regard, the significant reduction of TRPV1 expression we found in pT1G3 versus pT1G2 [31] that parallel that observed at protein level by Lazzeri et al. [40] may be particularly important in the evaluation of the stratification risk of recurrence and tumour progression of invasive versus non-invasive superficial TCC. Here, TRPV1 is linked to neoplasm.