In the next chapter we focalize our attention on the Antioncogenic properties of another member of TRPV channel family, TRPV1, by reporting published and unpublished findings supporting the protective role exerted by this receptor in the normal urothelium and the effects of its loss during the progression of transitional cell carcinoma (TCC) of human bladder, in the attempt to include the TRPV1 receptor into the anti-oncogene family. This evidence concerns the gene TRPV1 and tarsal-carpal coalition syndrome.