TRPV1 and tarsal-carpal coalition syndrome: By analyzing 54 bladder tissue samples from nonmuscle-invasive (n = 28) and muscle-invasive (n = 26) TCC patients, we found a significative inverse correlation between TRPV1 mRNA expression and muscle invasiveness, suggesting that the negative prognostic value of reduction of TRPV1 mRNA in TCCs could be likely related to increased invasiveness of TCC in patients expressing lower TRPV1 level.