In this regard, the involvement of miRNA and E3-ligases in the control of TRPV1 mRNA and protein expression, respectively, and the study on the existence of a relationship between the expression of specific TRPV1 gene single nucleotide polymorphisms (SNPs) and splice variants and increased cancer risk of TCC of human bladder have been approached. Here, TRPV1 is linked to tarsal-carpal coalition syndrome.