Notably, since reduction of TRPV1 expression in TCC of human bladder was significantly associated with a shorter survival of urothelial cancer patients, the analysis of TRPV1 expression in pT1 G2–G3 TCC shows the presence of a risk group stratification: the first group of pT1G2 TCC patients showing a reduction of TRPV1 expression (25% of total) and the second group showing a marked reduction of TRPV1 expression (50% of total) [31]. Here, TRPV1 is linked to tarsal-carpal coalition syndrome.