CD40LG and autoimmune polyendocrinopathy: Given the above background, we examined aPE and aPS of IgG and IgM antibodies in addition to LA, aβ2GPI, and aCL described in the classification criteria for definite APS and investigated the impact of antibody titers by classifying them into weakly (from the 95th to the 99th percentile) and strongly (over the 99th percentile), antibody isotypes of IgG and IgM, and the numbers of positive antibodies of single and multiple on reproductive outcome.