LRH-1 has also been implicated in the growth of liver tumors via reversal of repression by SHP: In vitro methylation of the SHP promoter reversibly decreased transactivation and LRH-1 binding; overexpression of SHP inhibited HCC foci formation, arrested HCC tumor growth in xenografted nude mice, and increased the sensitivity of HCC cells to apoptotic stimuli [59]. This evidence concerns the gene NR0B2 and hepatocellular carcinoma.