NFKB1 and interstitial nephritis: Data obtained in this study showed that p38 MAPK expression is increased during the development of gentamicin-induced interstitial nephritis and that such alteration is associated with enhancement of NF-κB expression and the inflammatory process in the renal cortex, suggesting that the p38 MAPK pathway may be involved in the renal lesions induced by gentamicin [93].