INS and diabetes mellitus: Larsen et al., using anakinra, a recombinant human IL-1Ra, in 70 patients with type 2 diabetes mellitus, observed after 13 weeks an improved β-cell secretory function (reduced glycated haemoglobin level, enhanced C-peptide secretion, reduced ratio of proinsulin to insulin) and a reduction of IL-6 and C-reactive protein, markers of systemic inflammation [61].