Unregulated choroidal angiogenesis begins when local inflammation, and potentially ischemia, disrupt a delicate interplay between numerous stimulators and inhibitors, which may lead to an imbalance between the proangiogenic vascular endothelial growth factor (VEGF) and the antiangiogenic pigment epithelium-derived factor (PEDF) [1]. The gene discussed is VEGFA; the disease is ischemia.