Although many genes, such as p53, mTOR, Ras, and Myc, have been implicated in the development of the Warburg effect, HIF-1 is the major player [5], [7], [8].We have studied MT1-MMP, a membrane type matrix metalloprotease (MMP), that promotes cancer cell invasion and growth in a collagen-rich tissue environment via its proteolytic activity. The gene discussed is MTOR; the disease is cancer.