The most abundant feature was gains or losses of domains, as observed in Limk2, Enah, Sox17, Aak1, Itsn1, and Plec1. The Lim, PDZ, and clathrin-binding domains disappeared in Limk2t and Aak1s during PAH [30], [31]. This evidence concerns the gene ITSN1 and pulmonary arterial hypertension.