Among the exon variants, hypertrophic signal-specific regulation was apparent in Egfl7 and Tmpo. According to the UCSC genome browser analysis, 3 different alternative promoters were involved in the AS for Egfl7. Significantly increased usage of the most distal promoter (i.e., Egfl7-1) was confirmed in PAH by RT-PCR; the usage of the promoter decreased in PHH [39]. This evidence concerns the gene EGFL7 and pulmonary arterial hypertension.