A brief exposure to ionizing radiation causes a major perturbation in nucleosome organization with release of 5–10% of the total amount of histone H1 to the cytosol [12], resulting in an estimated cytosolic concentration at the order of 10−4 M. Viral infection can lead to massive nucleosome disassembly triggered by expression of viral DNA-binding proteins [35]. This evidence concerns the gene H1-0 and viral infectious disease.