NDE1 and neoplasm: We examined the surgically-resected temporal cortex and hippocampus of two people with MTLE with identical 800 kb deletion at 16p13.11, encompassing seven genes, including NDE1 and ABCC1. In Case 1, the white matter of the temporal cortex contained a hamartia, which was not associated with any overlying cortical dyslamination or any dysmorphic neurons, balloon cells or more extensive changes seen in glio-neuronal tumours.