Since the presence of DUOX enzymes in the brain has not been firmly demonstrated, we first have analyzed by Western blotting the expression of DUOX1 and 2 proteins in rat brain, in a stabilized human oligodendrocytes cell line (M03-13) and in neuroblastoma (SK-N-BE) cells (Fig. 1A). The gene discussed is DUOX1; the disease is neuroblastoma.