HLA-C and infection: Many candidate genes concerned with susceptibility to infection per se, clinical manifestation, and reversal reaction have been studied to date, such as non-MHC genes VDR (12q13.11) [3]; NRAMP1 (2q35) [4, 5], TLR2 (4q32) [6], PARK2, and PACRG (6q25-q26) [7], and MHC genes DQB1, DQA1, DRB1 [8], MICA [9], TNFA [10], and C4B [11].