Sepramaniam et al. [145] investigated changes in aquaporin 1 and 4 expression in the MCAo rat brain and identified miR-320a as a potential negative modulator of AQP1 and AQP4. Anti-miR-320a could reduce infarct volume in cerebral ischemia with concurrent elevation in AQP1 and AQP4 mRNA and protein expression. The gene discussed is AQP1; the disease is brain ischemia.