APOE and coronary artery disorder: ApoE ε2 allele has been reported to be associated with higher plasma levels of apoE, decreased plasma levels of LDL cholesterol (LDL-C) and lower risk of CAD [14] while apoE ε4 is associated with lower plasma level of apoE, increased plasma levels of total cholesterol (TC), LDL-C, VLDL cholesterol (VLDL-C), and greater risk of CAD when compared to apoE3 homozygotes [15].