In a large multiethnic sample of US adults, we found that markers of SDB, including short sleep duration (<7 hours), long sleep duration (>7 hours), occasional or frequent snoring or snorting (>2 night/week), and daytime sleepiness (>1/month) had moderately strong positive associations with the presence of CRP levels > 1 mg/dL in an initial multivariable model adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, and physical activity. Here, CRP is linked to sleep apnea syndrome.