SRC and renal fibrosis: Both CTS-induced Na/K-ATPase signaling and oxidative stress are necessary in the pathogenesis of cardiac and renal fibrosis as evidenced by CTS-stimulated phosphorylation of both Src and MAPK which is effectively blocked not only by ROS scavenging and Src inhibition but also through possible competitive inhibition of CTS binding to Na/K-ATPase by spironolactone and canrenone [80, 84, 87, 88].