HMOX1 and obesity due to melanocortin 4 receptor deficiency: Besides, a blood pressure lowering effect, induction of HO-1 with CoPP has also previously been shown to reduce fasting blood glucose and plasma levels of inflammatory cytokines in obese male and female mice suggesting the potential beneficial effects of HO-1 in treating not only hypertension, but also the metabolic consequences of obesity such as insulin resistance and dyslipidemia [23].