The present study showed for the first time that a significant increase in serum NT-proBNP concentration exists in normotensive, healthy subjects harboring hypertension-related polymorphisms of GRK4, while there was no association between any of the hypertension-related genotypes studied and physiological indices (CAVI, AI, SBP, and cSBP), plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG. This evidence concerns the gene NPPB and Hypertension.