Moreover, deficiency of ACE2 in bone-marrow-derived stem cells had no effect on systemic concentrations of renin or AngII, similar to previous studies examining effects of renin deficiency in bone-marrow-derived cells on atherosclerosis in western diet-fed LDLR−/− mice [22]. The gene discussed is REN; the disease is hyperinsulinemic hypoglycemia, familial, 4.