Additional five papers belong to the experimental or basic aspects of hypertension; the role of C-reactive protein in atherosclerosis, the mechanisms related to hypertension in the elderly, the biochemical and molecular aspects of vascular adrenergic regulation of blood pressure, the putative role of protein Klotho in cardiovascular and renal disease, and, finally, the role of cortisol secretions in hypertensive elderly patients. The gene discussed is KL; the disease is Hypertension.