Zhang et al. [55] showed that a 5-day infusion of Ang-(1-7) improved glomerulosclerosis in a rat model of thy-1-induced glomerulonephritis, whereas Velkoska et al. [72] verified that a 10-day infusion of the same concentration of Ang-(1-7) in rats with subtotal nephrectomy was associated with deleterious effects on blood pressure and the heart, with increase in cardiac ACE, and decrease in cardiac ACE2 activity. The gene discussed is ACE2; the disease is glomerulosclerosis.