The physiopathological meaning of increased levels of only Ang-(1-7) in pediatric primary hypertension is still unknown and raises the question whether this elevation is a compensatory mechanism that opposes deleterious renal and cardiovascular effects of Ang II or whether, at supra physiological concentrations, Ang-(1-7) could act as another RAS mediator of renal dysfunction. Here, AGT is linked to essential hypertension.