Niessner et al asked: “Could the blockade of the RAF-MEK-ERK or/and PI3K-AKT-mTOR signalling pathways be a promising strategy for the treatment of melanoma brain metastases?” The results of their research suggest that activation of AKT is relevant for the survival and growth of melanoma cells in the brain parenchyma and that inhibition of PI3K-AKT signalling may be a suitable strategy to enhance and/or prolong the antitumor effect of BRAF inhibitors in melanoma brain metastases. This evidence concerns the gene MTOR and melanoma.