IGF1 and acromegaly: At a median followup of 30 months, Roug et al. [59] observed biochemical remission of disease, as defined by suppressed GH at OGTT and normal IGF-I levels adjusted for age, in 30% of 34 patients with active acromegaly, being 24%, 38%, and 64% after 1, 3, and 5 years, respectively.