In breast cancer, CXCL8 expression level strongly correlated with activating transcription factor 3 (ATF3), c-Jun and JunB, members of the AP-1 transcription factor complex [27], and ATF3 and JunB were also observed to be upregulated in the metastatic osteosarcoma samples investigated here. Here, CXCL8 is linked to osteosarcoma.