This model was previously used to model human invasive lobular breast carcinoma through conditional knockout of the adherens junction protein E-cadherin (K14-Cre/+;p53fl/fl;E-cadherinfl/fl), which enhanced tumor development and promoted metastasis relative to K14-Cre/+;p53fl/fl controls [37]. The gene discussed is KRT14; the disease is invasive lobular breast carcinoma.