The effects of NKCC1 antagonists on the four anxiety tests studied are unlike those of any of the major classes of medications with anxiolytic effects in humans (benzodiazepines, tricyclic antidepressants, SSRIs, SNRIs, and 5HT1A agonists), in that they appear to be specific to the conditioned models (see Table 3). Here, HTR1A is linked to Anxiety.