Because knockdown of Kv4.2, or Kv1.5 alone does not result in SD or HF [36]–[37], combined decreases in Kv4.2, Kv1.5 and KChIP2 may play an important role in the frequent premature SD in DCM mice. The gene discussed is KCNA5; the disease is familial dilated cardiomyopathy.