ADAMTS1 and colorectal cancer: Although ADAMTS1 promoter has been shown to contain CpG islands which are hypermethylated in colorectal cancer [21], our bisulfite sequencing and MeDIP results indicate that ADAMTS1 promoter is indeed hypomethylated in breast cancer-associated fibroblasts, normal breast tissue-associated fibroblasts or NAFs co-cultured with breast cancer cells (Fig. 5B, 5C and S2).