Our study further points out that the activation of ADAMTS1 in CAFs can be recapitulated in normal tissue-associated fibroblasts (NAFs) after their co-culture with breast cancer cells (Fig. 2), and that ADAMTS1 stimulation in cancer cell-cocultured NAFs can be sustained after the removal of the co-cultured cancer cells (Fig. 2). This evidence concerns the gene ADAMTS1 and breast cancer.