However, understanding the mechanisms controlling NSC trafficking in neuroinflammatory diseases such as MS is important and may enable these cells to be manipulated as means of improving their homing efficiency, for instance by altering extracellular matrix components during neural induction in order to modulate integrin expression [64] or by enforcing the expression of relevant homing, as demonstrated by ex vivo modification of CD44 isoforms on MSCs to improve trafficking to bone [65]. Here, CD44 is linked to myeloid sarcoma.