The increased expression of HO-1 has been observed in several cancers including brain tumor, melanoma, chronic myeloid leukemia, and lymphosarcoma [12], suggesting possible contribution of HO-1 to tumor progression through promotion of angiogenesis, metastases and pro-proliferation [13]. The gene discussed is HMOX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.