CFTR and cystic fibrosis: The loss of interactions between CFTR and other ion transporters have important consequences: the poor hydration of airways mucus and the reduced alkalization of pancreatic juice during CF are related to the loss of interaction between CFTR and the epithelial Na+ channel (ENaC) or between CFTR and the Cl-/HCO3- exchangers (SLC26A3 and A6), respectively [1], [2].