Furthermore, Kabuta et al. have shown that UCH-L1 interacts with members of the chaperon-mediated autophagy (CMA), and that the familial PD-associated UCH-L1I93M interacts abnormally with these members, leads to inhibition of CMA and as a result an increase in a-syn levels in cultured cells [61]. This evidence concerns the gene UCHL1 and Parkinson disease.