In the absence of STAT-6, mice did not develop Th2 responses, Ig class switching to IgE, AHR, mucus hypersecretion and airway eosinophilia upon allergen sensitization and airway challenges, highlighting the essential role of this transcription factor in the pathogenesis of allergic asthma [16], [38]. Here, IGHE is linked to Increased total eosinophil count.