Utilizing Genistein, a drug which we have previously shown to restore N-CoR native properties in APL [15] and AML-M5 cells (Nin et al, submitted manuscript), we first assessed the effect of Genistein induced stabilization of N-CoR on the restoration of its repressive function on wild type Flt3 in the AML-M5 cell line THP-1 (a cell line reported to express the wild type Flt3 receptor). Here, FLT3 is linked to acute promyelocytic leukemia.