With the observations in BA/F3 cells and our recent findings which linked Akt activity to N-CoR loss (Nin et al, submitted manuscript), we hypothesized that Flt3 activation by the Flt3 ligand might have potentiated the effects of N-CoR loss, thus amplifying the growth advantage in AML-M5. This evidence concerns the gene FLT3 and acute myeloid leukemia.