In our study, we found that N-CoR regulates the expression of both the wild-type (THP-1 and Nomo-1) as well as the activating mutants of Flt3 (MV-4-11: FLT3-ITD, MM1: FLT3-TKDat position 592) as N-CoR loss and reciprocal up-regulation of Flt3 gene expression was found uniformly across all the AML-M5 cell lines used (There are no known reports on the status of the Flt3 receptor in SigM5). Here, FLT3 is linked to acute myeloid leukemia.