Given N-CoR's documented importance in hematopoiesis and its role as a transcriptional co-repressor, we hypothesized that N-CoR loss in AML-M5 cells may have altered the expression profile of genes associated with the normal growth and maturation of hematopoietic cells, eventually contributing to malignant transformation. The gene discussed is NCOR1; the disease is acute myeloid leukemia.