Next to investigate the effects of N-CoR function restoration on the proliferative properties of AML-M5 cells expressing the various mutants of the Flt3 receptor, the status of N-CoR after Genistein treatment in a panel of AML-M5 cells (THP-1 and Nomo-1- both expressing wild type Flt3, MM1- expressing a constitutively active Flt3-TKD mutant due to an activating point mutation at position 592 in the kinase domain, MV-4-11-expressing the constitutively active Flt3-ITD mutant receptor and Sig M5-no published reports on the status of the Flt3 receptor) was assessed. Here, NCOR1 is linked to acute myeloid leukemia.