The immunoreactivity of A1R and A2AR detected in vGluT1/2-immunopositive terminals was similar in the 4 groups (Fig. 7C), whereas diabetes increased the fraction of vGAT-positive terminals endowed with either A1R or A2AR immunoreactivity by 30.7±1.3% (P<0.05, n = 4) and 17.9±3.9% (P<0.05, n = 4), respectively (Fig. 7D). Here, ADORA2A is linked to diabetes mellitus.