Moreover, the rate of CDH1 methylation was 95.7% (44/46) in GC tissues with lymph node metastasis, while was 67.4% (31/46) in GC tissues without lymph node metastasis, also with a significant difference between these two groups (χ2 = 12.195, P < 0.001). The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.