ARID1A and clear cell renal carcinoma: Indeed, four of the five cases reported here were also included in Wiegand et al9, with one case, PD3761a, having frameshift mutation in ARID1A. Also, ARID1A has been previously implicated in other human cancers 30, 31 and recently found to be mutated recurrently in clear cell renal cell carcinoma 32.